Is Phenergan a vesicant?

Problem: Promethazine (Phenergan, Wyeth) is a commonly used injectable product that possesses antihistamine, sedative, anti-motion sickness, and anti-emetic effects. The drug is also a known vesicant that is highly caustic to the intima of blood vessels and surrounding tissue.

What is a common side effect of Phenergan?

Drowsiness, dizziness, constipation, blurred vision, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor.

Where can I inject Phenergan?

It is best to inject this medication deep into a muscle. It may also be given by injection slowly into a large vein by a health care professional. Do not inject this medication under the skin or into an artery. For nausea and vomiting, use this medication as directed by your doctor, usually every 4 hours as needed.

Which drugs are Vesicants?

Vesicants: Drugs that can result in tissue necrosis or formation of blisters when accidentally infused into tissue surrounding a vein[14]. They include Actinomycin D, Dactinomycin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitomycin C, Vinblastine, Vindesine, Vincristine, and Vinorelbine.

Can you IV push Phenergan?

When administered intravenously, Phenergan Injection should be given in a concentration no greater than 25 mg per mL and at a rate not to exceed 25 mg per minute. It is preferable to inject through the tubing of an intravenous infusion set that is known to be functioning satisfactorily.

Does Phenergan cause extrapyramidal symptoms?

Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states.

What is better Zofran or Phenergan?

Phenergan has an average rating of 7.2 out of 10 from a total of 135 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 24% reported a negative effect. Zofran has an average rating of 8.0 out of 10 from a total of 211 ratings on Drugs.com.

What does Phenergan interact with?

CNS Depressants – Phenergan (Promethazine HCl) Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and …

Can Phenergan be given IM in the arm?

The usual dose is 25 – 50 mg by deep intramuscular injection, or, in emergency, by slow intravenous injection after dilution of the 2.5% solution to 10 times its volume with water for injections immediately before use. Maximum parenteral dose 100 mg.

Is Zofran a vesicant?

Examples of non-vesicant solutions and medications include: Many antibiotics. Solumedrol (steroid) Ondansetron (Zofran) – anti-nausea drug.

What is an example of a vesicant?

Vesicants include distilled mustard (HD), mustard gas (H), lewisite, mustard/lewisite, mustard/T, nitrogen mustard, phosgene oxime, sesqui mustard, and sulfur mustard.

Why Phenergan is not given IV?

Under no circumstances should Phenergan Injection be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene (see WARNINGS – Severe Tissue Injury, Including Gangrene). Subcutaneous injection is contraindicated as it may result in tissue necrosis.

Do you have to dilute Phenergan IV?

DO NOT GIVE IV PUSH – MUST DILUTE FIRST AND ADMINISTER BY SLOW IV INFUSION- SEE BELOW. PREFERRED ROUTES: IM OR ORAL. Subcutaneous or intra-arterial injection is contraindicated as these routes of administration may cause tissue necrosis and gangrene of the affected extremity, respectively (Prod Info Phenergan(R),).

Can promethazine cause akathisia?

Akathisia refers to mental and motor restlessness that makes it difficult for the patient to sit still. In addition to prochlorperazine, several other dopamine antagonists that can cause akathisia are commonly administered in the ED, including metoclopramide, promethazine, haloperidol, and droperidol.

Does Phenergan affect heart rate?

Heart rate disturbances, dry mouth, confusion, tinnitus (a ringing in the ears), double vision, anxiety, and dizziness have also been reported. Rarely, respiratory depression (unusually slow and shallow breathing); children are more at risk.

Does Phenergan interact with other medications or foods?

Common medications that may interact with Phenergan include: other medications used to treat allergies. Alcohol may enhance the sedative effects of Phenergan. May cause false-negative or false-positive results in pregnancy tests that are based on immunological reactions between HCG and anti-HCG.

Can chemotherapeutic agents with vesicant properties cause blisters?

There are several chemotherapeutic agents with vesicant properties, and when inadvertently infused into the surrounding tissue from an infiltrated IV, these agents may have the potential to cause blisters, severe tissue injury or necrosis, known as extravasation.

Is promethazine (Phenergan) safe?

PA PSRS Patient Saf Advis 2007 Mar;4 (1):7-10. First approved by the U.S. Food and Drug Administration (FDA) in 1951, promethazine (Phenergan) is a medication in common use today. However, despite its familiarity, its use is not without risks.

Does Phenergan inhibit platelet aggregation in newborns?

Use of Phenergan within two weeks of delivery may inhibit platelet aggregation in the newborn. It is not known if Phenergan is excreted into human milk.