What is Acantholytic Acanthoma?

Acantholytic dyskeratotic acanthoma (ADA) is a rare benign condition characterized by circumscribed epidermal proliferation displaying both acantholysis and dyskeratosis. Most cases are clinically diagnosed as basal cell carcinoma, which leads to their excision and histopathologic examination.

What causes Acantholysis?

The cause of transient acantholytic dermatosis is unknown. Due to the frequent association with skin occlusion, heat, and sweating, one theory suggests Grover disease is due to sweat duct damage and occlusion.

What is a warty Dyskeratoma?

Warty dyskeratoma (WD) is a benign epidermal proliferation first reported in 1957 because of its distinctive histologic findings. WD presents as an umbilicated papule with a keratotic plug, usually limited to the head, neck, or face.

What does acanthoma look like?

Large cell acanthoma occurs as a sharply demarcated, scaly, often lightly pigmented patch, approximately 3 to 10 mm in diameter, on the sun-exposed skin of middle-aged and elderly individuals. Conjunctival lesions have been reported. It is usually solitary. Clinically, it resembles a seborrheic or actinic keratosis.

What does Grover’s disease look like?

The main symptoms of Grover’s disease are: Sudden rash on the chest, back, and sometimes arms and legs. Blisters containing a thin, watery liquid with a hair follicle in the center. Blisters clumped together, surrounded by a red swollen ring.

What is focal Acantholysis?

Focal acantholytic dyskeratosis (FAD) is a distinctive histologic pattern characterized by suprabasilar clefts surrounding dermal papillae (villi), acantholytic and dyskeratotic cells at all levels of the epidermis, hyperkeratosis, and parakeratosis.

What can be mistaken for Grover’s disease?

Sometimes people may confuse Grover’s disease with other conditions, including:

• Darier disease: Unlike Grover’s disease, Darier disease usually appears during or just after puberty (before age 30) and is hereditary.
• Hailey-Hailey disease: This disease involves blisters and crusted skin bumps, but is genetic.

What does pemphigus look like?

Pemphigus affects the outer of the skin (epidermis) and causes lesions and blisters that are easily ruptured. Pemphigoid affects a lower layer of the skin, between the epidermis and the dermis, creating tense blisters that do not break easily. Sometimes pemphigoid may look like hives or eczema without blisters.

What does pemphigus foliaceus look like?

What does pemphigus foliaceus look like? Pemphigus foliaceus usually first manifests in adulthood (average 50 to 60 years) but childhood cases can occur. The condition often first presents with an eruption on the face or scalp which looks red and scaly.

What is Darier disease?

Darier disease, also known as Darier-White disease, keratosis follicularis, or dyskeratosis follicularis (MIM #124200), is a rare autosomal dominant genodermatosis characterized by a persistent eruption of red-brown, keratotic papules scattered to confluent in a seborrheic distribution, nail abnormalities, pitting of …

What are Corps Ronds?

Corps ronds refer to cells with small pyknotic nuclei, a perinuclear clear halo and eosinophilic cytoplasm (Figures 4 and 5). Grains are compressed cells with elongated nuclei seen in the stratum corneum and granular layer (Figures 4 and 5).

Is Acanthoma benign?

ACANTHOMAS. Acanthomas are benign tumors of epidermal keratinocytes.

Is Acanthoma malignant?

It is usually solitary. Clinically, it resembles a seborrheic or actinic keratosis. Large cell acanthoma is thought to comprise sunlight-induced clones of abnormal cells, without a tendency to malignancy.

What is a Warty dyskeratoma?

Warty dyskeratoma. Warty dyskeratoma, also known as an Isolated dyskeratosis follicularis, is a benign epidermal proliferation with distinctive histologic findings that may mimic invasive squamous cell carcinoma and commonly manifests as an umbilicated (Having a central mark or depression resembling a navel) lesion with a keratotic plug,…

What are the symptoms of warts on a horse?

Symptoms of warts are straightforward but can vary from one to another. Warts can vary in size and appearance, even though on the same horse and in the same area. The warts can be gray/white in color and cauliflower-like in appearance including short stalks attaching themselves to the skin.

What is the histologic pattern of acantholytic dyskeratosis?

As the histologic pattern is an epidermal reaction pattern of acantholytic dyskeratosis, the differential diagnosis often includes Grover’s disease, Darier’s disease, and acantholytic actinic keratosis or squamous cell carcinoma. Therefore, clinicopathologic correlation is necessary.