What is the pathophysiology of diabetes mellitus?

The pathophysiology of diabetes involves plasm concentrations of glucose signaling the central nervous system to mobilize energy reserves. It is based on cerebral blood flow and tissue integrity, arterial plasma glucose, the speed that plasma glucose concentrations fall, and other available metabolic fuels.

What is the pathophysiology of diabetes mellitus type 1?

Type 1 DM is the culmination of lymphocytic infiltration and destruction of insulin-secreting beta cells of the islets of Langerhans in the pancreas. As beta-cell mass declines, insulin secretion decreases until the available insulin no longer is adequate to maintain normal blood glucose levels.

What is the basic underlying pathophysiology of type II DM?

Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders worldwide and its development is primarily caused by a combination of two main factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond to insulin [1].

What is the classification of DM?

The vast majority of diabetic patients are classified into one of two broad categories: type 1 diabetes mellitus, which is caused by an absolute or near absolute deficiency of insulin, or type 2 diabetes mellitus, which is characterized by the presence of insulin resistance with an inadequate compensatory increase in …

What is the pathophysiology of hyperglycemia?

Pathophysiology. Hyperglycemia in a patient with type 1 diabetes is a result of genetic, environmental, and immunologic factors. These lead to the destruction of pancreatic beta cells and insulin deficiency. In a patient with type 2 diabetes, insulin resistance and abnormal insulin secretion lead to hyperglycemia.

What is the pathophysiology of hypoglycemia?

Hypoglycemia is characterized by a reduction in plasma glucose concentration to a level that may induce symptoms or signs such as altered mental status and/or sympathetic nervous system stimulation. This condition typically arises from abnormalities in the mechanisms involved in glucose homeostasis.

What are the 4 major types of diabetes?

There are four main types of diabetes: Type 1 diabetes, Type 2 diabetes, gestational diabetes, and a condition known as prediabetes, in which you have higher-than-normal blood glucose levels but not quite high enough (yet) to qualify as Type 2 diabetes.

What is pathophysiology Slideshare?

Pathophysiology = the study of the functional changes associated with a specific disease  The study of abnormal function in the body and how disease processes work  How the disease affects specific functions of the body INTRODUCTION TO Pathophysiology.

What are topics in pathophysiology?

Pathophysiology includes four interrelated topics: etiology, pathogenesis, clinical manifestations, and treatment implications.