Can meropenem cause seizures?

For meropenem, doripenem, and ertapenem, the seizure rate for each agent is reported as less than 1%. However, as their use increases and expands into new patient populations, the rate of seizures with these agents may increase.

Can cefepime cause seizures?

Cefepime is a widely used antibiotic with neurotoxicity attributed to its ability to cross the blood–brain barrier and exhibit concentration-dependent ϒ-aminobutyric acid (GABA) antagonism. Neurotoxic symptoms include depressed consciousness, encephalopathy, aphasia, myoclonus, seizures, and coma.

What is the best drug of choice for status epilepticus?

BENZODIAZEPINES. The benzodiazepines are some of the most effective drugs in the treatment of acute seizures and status epilepticus. The benzodiazepines most commonly used to treat status epilepticus are diazepam (Valium), lorazepam (Ativan), and midazolam (Versed).

Which carbapenems cause seizures?

Abstract. Objectives: A consensus exists among clinicians that imipenem/cilastatin is the most epileptogenic carbapenem, despite inconsistencies in the literature.

Which carbapenem has highest seizure risk?

In general, the incidence of seizures associated with carbapenems is as follows, in order of decreasing frequency: Meropenem (0.7%) [6], ertapenem (0.5%) [7], and imipenem (0.4%) [8], according to FDA-approved labeling; but compared to other carbapenems, the highest seizure rate has occurred with the use of imipenem ( …

Which antibiotics can lower seizure threshold?

Numerous antibiotics may trigger epileptic seizures or status epilepticus by decreasing inhibitory transmission in the brain, thus lowering the seizure threshold. The most potent seizurogenic effect is exerted by penicillins, cephalosporins, fluorochinolons and carbapenems.

Can cefepime causing encephalopathy?

Use of cefepime by patients may cause symptoms of encephalopathy, such as impaired consciousness, myoclonic seizures and non-convulsive status epilepticus.

What is the immediate IV treatment for status epilepticus?

Intravenous benzodiazepines-diazepam, midazolam or lorazepam and phenytoin are the first line drugs recommended for termination of seizures. Diazepam (or midazolam), thiopental and propofol infusion are useful for control of Refractory SE (RSE). Newer drugs are being investigated for use in SE.

Can imipenem cause seizures?

Abstract. Imipenem-cilastatin is a broad spectrum antibiotic that is generally used for antibiotic-resistant hospital-acquired infections. Imipenem has been reported to cause CNS toxicity including seizures in 1.5-10% of patients.

Which carbapenem does not cause seizures?

What is the difference between epilepsy and status epilepticus?

If you have epilepsy, you may have seizures repeatedly. A seizure that lasts longer than 5 minutes, or having more than 1 seizure within a 5 minutes period, without returning to a normal level of consciousness between episodes is called status epilepticus.

What triggers status epilepticus?

In children, the main cause of status epilepticus is an infection with a fever. In adults, the common causes include: Stroke. Imbalance of substances in the blood, such as low blood sugar.

What drugs should epileptics avoid?

Epilepsy drugs known to have this effect include Carbatrol, Dilantin, phenobarbital, Mysoline, Trileptal, and Topamax.

What antibiotics should epileptics avoid?

The main classes of antibiotics associated with a risk of seizures are unsubstituted penicillins, fourth-generation cephalosporins, and imipenem. The risk of seizures appears to be consistently associated with high doses, renal dysfunction, brain lesions, or known epilepsy.