What is plasmablastic myeloma?

What is plasmablastic myeloma?

Plasmablastic myeloma is a subtype of MM in which ≥2% of the clonal plasma cells are morphologically plasmablasts (6). It is a very rare and aggressive MM subtype, seen in about 5-10% of patients with MM and associated with an overall poor prognosis and survival (6, 7).

Is Plasmablastic lymphoma cancerous?

Plasmablastic lymphoma (PbL) is an aggressive B-cell malignancy highly associated with HIV. A fraction of large B-cell lymphomas (LBCL) share a plasmablastic differentiation with an aggressive behavior, refractoriness to chemotherapy, and poor prognosis in most cases.

What type of cancer is Plasmablastic lymphoma?

Plasmablastic lymphoma (PBL) is an uncommon but aggressive subtype of diffuse large B-cell lymphoma. The diagnosis of PBL is difficult because its features overlap with myeloma and lymphoma. The primary organs involved are usually the gastrointestinal system, lymph nodes, oral mucosa and sometimes the skin.

What is the survival rate of Plasmablastic lymphoma?

The 3-year and 5-year overall survival (OS) rates of treated PBL patients were 54% (95% CI: 46.5%-60.8%) and 52.8% (95% CI: 45.2%-59.8%). Three-year conditional survival for 2-year and 3-year survivors were 90.3% and 97.8%, overlapping the survival of a general population matched by age, sex and calendar year.

What is Plasmablastic leukemia?

Abstract. Plasmablastic lymphoma (PBL) is an aggressive malignancy that usually occurs in the setting of immunosuppression. The immunohistochemical profile of PBL is that of terminally differentiated B lymphocytes. CD138, CD38, and MUM1 are usually immunopositive.

What is a Plasmablast?

In immunology, a “plasmablast” refers to a short-lived differentiation stage between a post germinal centre B-cell and a mature plasma cell. Plasmablasts retain a proliferative capability together with an almost fully mature plasma cell phenotype [1].

Is Plasmablastic lymphoma curable?

Plasmablastic Lymphoma Is Curable The HAART Era. A 10 Year Retrospective By The AIDS Malignancy Consortium (AMC) | Blood | American Society of Hematology.

Is Plasmablastic lymphoma non-Hodgkin?

Plasmablastic lymphoma (PBL) is an aggressive subtype of non-Hodgkin’s lymphoma (NHL), which frequently arises in the oral cavity of human immunodeficiency virus (HIV) infected patients.

Can Plasmablastic lymphoma be cured?

Is Plasmablastic lymphoma non Hodgkin?

What is Plasmablastic morphology?

Plasmablastic morphology was considered to be present (plasmablastic myeloma) when 2% or more plasmablasts were present in the plasma-cell population. Results: Patients underwent transplantation 5 to 88 months (median, 20 months) after the initial diagnosis of myeloma.

Where are Plasmablast found?

Plasmablasts are generated in secondary lymphoid organs. They become migratory, leave the spleen/lymph nodes guided via S1P1, and travel via the blood to the bone marrow parenchyma.

What does Plasmablastic mean?

(PLAZ-muh-BLAS-tik lim-FOH-muh) A very aggressive (fast-growing) type of large B-cell non-Hodgkin lymphoma (cancer that begins in the cells of the immune system).