What is the function of p21 and p27?

The CDK inhibitors p21 and p27 regulate the cell cycle by inhibiting the functions of the various CDK proteins as indicated. Abbreviations: CDK, cyclin-dependent kinase; P, phosphorylation. CDKs were identified by virtue of the fact that mutations of these proteins in yeast affected their growth rates (Refs 7, 8).

What is the role of p21 in cell division?

The cyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals.

What is p21 apoptosis?

P21 is a cell cycle inhibitor that is involved in essential cellular processes such as cell cycle arrest, apoptosis, and transcriptional regulation, as well as differentiation, senescence, and DNA repair.

What is the function of p27?

Within cells, p27 is located primarily in the nucleus, where it plays a critical role in controlling cell growth and division. It helps regulate the cell cycle, which is the cell’s way of replicating itself in an organized, step-by-step fashion.

What is p27 in cell cycle?

p27 is a key regulator of cell proliferation. While it opposes cell cycle progression by binding to and inhibiting cyclin E-Cdk2, T157/T198 phosphorylation of p27 promotes its assembly of D-type cyclin-CDKs. In addition to its actions on the cell cycle, p27 regulates CDK-independent cytoplasmic functions.

What is a p21 gene?

p21 is an inhibitor of cyclin-dependent kinase and acts to prevent protein retinoblastoma (pRb) phosphorylation by inhibiting activation of cyclin E/cdk2 complexes that are required for Rb phosphorylation. Expression of p21 is regulated by a number of signaling molecules, including p53 and K-ras.

What is the role of p27?

p27 is a member of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors, which functions to negatively regulate cell cycle progression at the G1/S boundary in response to antiproliferative stimuli.