What is Thymoglobulin infusion?

This medication is used to prevent and treat rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by decreasing your body’s natural defense (immune system).

Is thymoglobulin the same as ATG?

Uses. Two antithymocyte globulin (ATG) agents licensed for clinical use in the United States are Thymoglobulin (rabbit ATG, rATG, Genzyme) and Atgam (equine ATG, eATG, Pfizer).

How is thymoglobulin?

Thymoglobulin is made by taking donated human white blood cells (T-lymphocytes) and injecting them into a rabbit. The rabbit’s blood makes its own antibodies (a blood protein) against these T-lymphocytes. These antibodies are then taken from the rabbit’s blood and made into Thymoglobulin.

Can thymoglobulin be given peripherally?

The recommended route of administration for Thymoglobulin is intravenous infusion using a high flow vein; however, it may be administered through a peripheral vein.

What is Thymoglobulin induction therapy?

Background: Induction therapy is used to reduce the incidence of graft rejection and delayed graft function. Thymoglobulin is the most used inductor agent in deceased donor kidney transplantation due to its lower rejection and delayed graft function rates.

How long does it take for ATG to work?

After 6 months, in the horse ATG group, 178 of 292 evaluable patients achieved a response (61%) including 56 (19%) who achieved a complete response and 122 (42%) who achieved a partial response.

What is the generic name for thymoglobulin?

GENERIC NAME: LYMPHOCYTE IMMUNE GLOBULIN, ANTI-THYMOCYTE GLOBULIN (RABBIT) – INJ (LIM-foe-site, AN-ti THIGH-mow-site)

How is basiliximab administered?

Reconstituted Simulect® should be given either as a bolus injection or diluted to a volume of 25 mL (10 mg vial) or 50 mL (20 mg vial) with normal saline or dextrose 5% and administered as an intravenous infusion over 20 to 30 minutes.

Is thymoglobulin an immunoglobulin?

Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a purified polyclonal immunoglobulin used for prevention and treatment of acute rejection (AR) following renal transplantation.

How ATG treatment is done?

ATG is a drug made of antibodies that suppress the immune system. It is made by injecting horses with white blood cells from humans, called lymphocytes. By injecting the horses with these human lymphocytes, the horse’s immune system produce antibodies directed against these human lymphocytes.

How is thymoglobulin produced?

Thymoglobulin is produced by immunizing pathogen-free New-Zealand rabbits with fresh human thymocytes, obtained from cardiac surgery donors. The final product is a purified, pasteurized preparation of polyclonal Ig, produced in rabbits to act against human thymocytes.

What is basiliximab for?

Basiliximab injection is used with other medications to prevent immediate transplant rejection (attack of the transplanted organ by the immune system of the person receiving the organ) in people who are receiving kidney transplants. Basiliximab injection is in a class of medications called immunosuppressants.

What is the half life of basiliximab?

Basiliximab has a high volume of distribution, almost completely saturating IL-2R on peripheral lymphocytes within 24 hours of a single dose of 2.5–25 mg in renal transplant recipients. The half-life in adults is approximately 13.4 days, and IL-2R saturation and suppression can last for 4–6 weeks.

Can Thymoglobulin be given peripherally?

What is the generic name for Thymoglobulin?