Where is Alpha-ketoglutarate found?

Where is Alpha-ketoglutarate found?

Overview. Alpha-ketoglutarate is a chemical found in the body. People use it to make medicine. Alpha-ketoglutarate is used for kidney disease, intestinal and stomach disorders, and many other conditions but there is no good scientific evidence to support most of these uses.

What is the structure of alpha-ketoglutarate?

C5H6O5α-Ketoglutaric acid / Formula

What is calcium alpha-ketoglutarate monohydrate?

Calcium-alpha-ketoglutarate (C5H4CaO5•H2O) is a special form mineral calcium that can be used to restore calcium concentration level in the blood back to normal. Calcium-alpha-ketoglutarate binds excess phosphate and pass it as a waste, re-establishing normal balance of calcium and phosphate in the body.

What does Alpha-ketoglutarate dehydrogenase do?

Alpha-ketoglutarate dehydrogenase (α-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. It catalyses the conversion of α-ketoglutarate to succinyl-CoA and produces NADH directly providing electrons for the respiratory chain.

What is AKG in medicine?

AKG (alpha-ketoglutarate) is the nitrogen-free portion of the amino acids known as glutamine and glutamic acid. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells.

Is alpha-ketoglutarate an acid?

Its anion, Alpha-ketoglutarate (also called oxo-glutarate) is an important biological compound. It is the keto acid produced by de-amination of glutamate, and is an intermediate in the Krebs cycle….

Alpha-ketoglutaric acid
Molar mass 146.11 g/mol
Melting point 113.5

What is arginine AKG used for?

(arginine alpha-ketoglutarate) is a compound made from the amino acid L-arginine and alpha-ketoglutarate (AKG) a substance formed in the body’s energy-generating process. It has been speculated that AAKG may increase production in muscles of nitric oxide, a substance known to have blood-flow-enhancing effects.

Is CA AKG same as AKG?

What is Calcium Alpha-Ketoglutarate? Ca-AKG is a stable form of the naturally occurring substance, alpha-ketoglutarate (AKG) which is produced by our bodies up until the age of approximately 40, after which it radically decreases.

What is alpha-ketoglutarate dehydrogenase deficiency?

Alpha-ketoglutarate dehydrogenase deficiency is a congenital error of an enzyme in the citric acid cycle. It is thought to be caused by low molar ratios of ketone bodies in the plasma of neonates with congenital lactic acidosis.

Is ketoglutarate dehydrogenase reversible?

We previously identified KGDH as an enzyme that undergoes reversible glutathionylation and inhibition in response to treatment of mitochondria with H2O2 ( 13, 14). KGDH limits the rate of certain functional parameters of the mitochondria and is regulated by a variety of metabolites (15−19, 25) .

When should I take alpha-ketoglutarate?

Sometimes healthcare providers administer alpha-ketoglutarate intravenously for preventing injury to the heart resulting from blood flow issues during heart surgery and for preventing muscle loss following surgery or trauma.

Is AKG Samsung?

It is a part of Harman International Industries, a subsidiary of Samsung Electronics.

What is AKG medical?

AKG (alpha-ketoglutarate) is used by cells during growth and in healing from injuries and other wounds , and is especially important in the healing of muscle tissue. A controlled study found that intravenous AKG prevented a decline in protein synthesis in the muscles of patients recovering from surgery.

Is Ca-AKG water soluble?

Our Calcium AKG is anhydrous as opposed to monohydrate. This is because monohydrate has a water molecule and anhydrous doesn’t. This means that as well as anhydrous being the preferred nutrition grade as it is more soluble (your body can absorb it more effectively), it contains more of the active compounds.

What is succinate dehydrogenase deficiency?

Succinic semialdehyde dehydrogenase deficiency is a disorder that can cause a variety of neurological problems. People with this condition typically have developmental delay, especially involving speech development; intellectual disability; and decreased muscle tone (hypotonia) soon after birth.

What is Oxoglutarate used for?

The tricarboxylic acid (TCA) cycle intermediate 2-oxoglutarate (2-OG) is used as an obligatory substrate in a range of oxidative reactions catalyzed by 2-OG-dependent dioxygenases. These enzymes are widespread in nature being involved in several important biochemical processes.

What are the enzymes in alpha ketoglutarate dehydrogenase complex?

α-KGDC is a complex consisting of multiple copies of three enzymes: α-ketoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).