What is the role of substance P?

Substance P’s most well-known function is as a neurotransmitter and a modulator of pain perception by altering cellular signaling pathways. Additionally, substance P plays a role in gastrointestinal functioning, memory processing, angiogenesis, vasodilation, and cell growth and proliferation.

What does the P stand for in substance P?

Substance P (SP) is an undecapeptide that derives from alpha, beta, and gamma pre-protachykinin gene transcripts and is a neurotransmitter or neuromodulator of primary nociceptive afferents (178).

What is substance P in skin?

Substance P (SP), the main neuropeptide identified in skin nerve endings, is essentially located in primary afferent C-fibers and is released in the skin [6].

What triggers substance P?

P isn’t just for pain Yet, substance P is pervasive in the amygdala, a brain region associated with stress, pleasure and addiction. Like a key that opens a lock, substance P activates a receptor known as neurokinin-1. They work together as a signaling system to help the body respond to stress.

What is substance P in Fibromyalgia?

Substance P is a neurotransmitter that is released when axons are stimulated. Elevated levels of substance P increase the sensitivity of nerves to pain or heighten awareness of pain.

What is substance P acne?

Substance P causes proliferation and differentiation of sebaceous glands and increases lipid synthesis in sebocytes. Purpose: To determine the correlation between stress scale and serum substance P level in acne vulgaris.

What causes elevated substance P?

Elevation of serum, plasma, or tissue SP and/or its receptor (NK1R) has been associated with many diseases: sickle cell crisis; inflammatory bowel disease; major depression and related disorders; fibromyalgia; rheumatological; and infections such as HIV/AIDS and respiratory syncytial virus, as well as in cancer.